This post teaches you how to fix error code 0x80042109 manually.
1. Open Outlook 2007, click on Tools > Account Settings > double click on the problem email account > click on More Settings > Advanced.
(by: ophtek.com) 2. set the SMTP Port number as 587 for the Outgoing Server and Encryption as TLS
(by: slipstick.com) check the My Outgoing Server requires Authentication option under the Outgoing Server tab in More Settings.
Other options: Update your Microsoft Outlook 2002/2003@ www.microsoft.com/download/en/office.aspx?q=office and/or XP Disable any Anti-Virus or (MS Windows) Firewall@ (Control Panel\System and Security\Windows Firewall) Remove and re-create your email account in Outlook